Natsuki Ishizuka, Ken-ichi Matsumura, Katsunori Sakai, Masafumi Fujimoto, Shin-ichi Mihara, and Teruo Yamamori
Structure-Activity Relationships of a Novel Class of Endothelin-A Receptor Antagonists and Discovery of Potent and Selective Receptor Antagonist, 2-(Benzo[1,3]dioxol-5-yl)-6-isopropyloxy-4-(4-methoxyphenyl)-2H-chromene-3- carboxylic Acid (S-1255). 1. Study on Structure-Activity Relationships and Basic Structure Crucial for ETA Antagonism
Journal of medicinal chemistry 2002, Vol.45 issue 10 p. 2041 - 2055
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http://dx.doi.org/10.1021/jm010382z