Сообщение
Pax » Сб апр 16, 2011 5:43 pm
Вот, что нашел в Modern Pharmacology and Clinical application - Charles R. Craig, Robert E. Stitzel - 2007 год кажется.
Siberian ginseng (Eleutherococcus senticosus)
should not be confused with Panax ginseng. Although it belongs to the same plant family (Araliaceae), it is a much larger, more abundant, and consequently less ex-
pensive plant. Like Panax ginseng, however, it is used as a tonic and adaptogen, a nonmedical term meaning that it helps the body adapt to stress in a variety of ways.
Siberian ginseng does contain saponins (eleutherosides) but no ginsenosides. To date, in spite of its popularity, there is little conclusive evidence of clinical efficacy.
Mechanism of Action
Ginsenosides are thought to be the active principles in Panax ginseng root. The various subtypes can have opposing pharmacological actions: Rg1 stimulates the cen-
tral nervous system (CNS) and elevates blood pressure, while Rb1 does just the opposite. Somehow these multiple ginsenoside constituents are thought to act in con-
cert to provide increased stamina. In addition, these compounds have antiplatelet aggregation effects and antioxidant properties, and they may stimulate the im-
mune system.
Adverse Reactions, Contraindications, and Interactions
Ginseng is generally considered safe for nonpregnant healthy adults; however, at sufficient doses, ginseng may elevate blood pressure and cause insomnia, palpita-
tions, nervousness, and tremor in susceptible individuals. These effects are increased if caffeine or other stimulants are taken concurrently. Both Panax and Siberian
ginsengs should definitely be avoided in any patient with poorly controlled hypertension. Dizziness, headache, diarrhea, and nausea have also been re-
ported. A controversial ginseng abuse syndrome consisting of tremor, elevated blood pressure, insomnia, and anxiety may also occur.
Diabetic patients have had hypoglycemia on ginseng, so sugars must be monitored, and insulin or other hypoglycemic medication dosages may have to be reduced.
The use of ginseng with anticoagulants (e.g., warfarin) and antiplatelet drugs is to be avoided because of the theoretical risk of increased bleeding. Also, co-administration of
ginseng with digoxin and MAOIs should be avoided.
Толком нигде ничего не написано. Соотв. механизм передозировки, как я понимаю, состоит в простейшем торможении нервной деятельности в следствии предшествующего чрезмерного возбуждения. Как-то так, поправьте, если ошибаюсь.)
Дозы, порядок приема...
