Нужен о-фторфенол

[Zord]

Нужен о-фторфенол в количестве 70-100 г., в Москве. Куплю или поменяю на что либо.

[maks]

буржуазный 100гр, 98%, 150 $ , 50гр -125$

[gert verheyen]

Есть грамм 10 о-фенолята натрия...Расстанусь

[Zord]

буржуазный 100гр, 98%, 150 $ , 50гр -125$

Ну если бы 50г за 75$ или дешевле, то взял бы.

[maks]

http://www.alfa.com/en/GP100w.pgm?DSSTK=A14979

как видите мне это обходится 68$ плюс НДС , плюс еще 30 Козлевичу который это привезет , интерес минимальный

[Zord]

Это понятно, каталожные дорогие, может что попроще есть, как тут пишут китайское что нибудь?

[maks]

у китайцев все дешево когда речь идет 300$ реагенте в каталоге и выше , а с пересылкой на относительно дешевые так на так получается , увы

[Любитель_Манниха]

Если вдруг пригодиццо, кажется у мну есть о-бромфенол
Реаксис правда знает только одну методику обмена, от 2010 года

Код: Выделить всё

Efficient Synthesis of Aryl Fluorides†

    Pazhamalai Anbarasan Dr.,
    Helfried Neumann Dr.,
    Matthias Beller Prof.

Angewandte Chemie International Edition

Volume 49, Issue 12, pages 2219–2222, 


General procedure for the preparation of Grignard reagents with direct Mg insertion in the presence of LiCl: To a Schlenk tube flushed with argon was added Mg (5.5 mmol), LiCl (5 mmol), and then THF (1.5 mL). To the slurry 0.2 mL of a solution of aryl bromide in THF (5 mmol was dissolved in 3.5 mL) was added and stirred vigorously. The formation of Grignard reagents was initiated in one minute (which was realized by the generation of heat), then remaining aryl bromide was added slowly by maintaining the same temperature. After the addition of aryl bromide the reaction mixture was stirred for 15–30 min at RT. The quantitative estimation of Grignard was carried out by GC analysis with hexadecane as THE internal standard.

General procedure for the preparation of Grignard reagents via Br/Mg exchange with iPrMgCl⋅LiCl: To a Schlenk tube flushed with argon was added iPrMgCl⋅LiCl (5.5 mmol, 1.3 M solution in THF). Neat aryl bromide (5 mmol) was added in portions over 20–30 min at 0 °C. The reaction mixture was stirred for 1–3 h. Quantitative estimation of formed Grignard reaction was achieved by GC analysis with hexadecane as the internal standard.

General procedure for the fluorination of Grignard reagents with N[BOND]F reagent: To a dry Schlenk tube flushed with argon was added the N[BOND]F reagent (0.75 mmol) followed by the respective solvent (2 mL) and cooled to 0 °C (Table 3). A solution of Grignard reagent in THF (≈0.5 mmol in 0.5 mL of THF) was added very slowly over 45–50 min using the syringe pump technique. After the addition, the reaction mixture was stirred for 45 min at the same temperature and quenched by addition of saturated aq NH4Cl. The yield of fluorinated product was determined by GC analysis of the organic phase with hexadecane as the internal standard.