By Vittorio Caprio, Jonathan Williams
* Publisher: Wiley-Blackwell
* Number Of Pages: 408
* Publication Date: 2009-03-09
* ISBN-10 / ASIN: 1405175192
* ISBN-13 / EAN: 9781405175197
Product Description:
Controlling the stereochemical outcome of reactions in the synthesis of complex natural products or bioactive materials represents a considerable intellectual and practical challenge for chemists. The stereochemical features of these products are usually essential to their bioactivity, so asymmetric synthesis has become a dominant feature of modern organic chemistry. Asymmetric catalysis is an important aspect of asymmetric synthesis, and one that has seen significant progress in the development of widely applicable methodology. This book is written from the point of view of the synthetic organic chemist, illustrating the transformations that can be achieved via this methodology, rather than the organometallic chemistry that lies behind. The emphasis is on non-enzymatic methods of asymmetric catalysis, although key references to enzyme-catalysed reactions have been incorporated where appropriate.
The book is extensively referenced and therefore provides a convenient point of entry to the primary literature for both experienced synthetic organic chemists and advanced students alike.
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ISBN: 9788122424850
Product information:
The book Principles of Organic Medicinal Chemistry describes the principles and concepts of chemistry, synthetic schemes, structure activity relationships, mechanism of action and clinical uses of carbon compounds in the light of modern trends. The book covers the syllabi of B.Pharmacy and M.Pharmacy courses of all Indian Universities.
This book comprises of 22 chapters. Chapter 1 gives an introduction to medicinal chemistry, Chapter 2 explain about the basics on principles of drug action and physicochemical properties of organic medicinal, substances are elaborated in Chapter 3. The concepts of Prodrugs and Drug metabolism are summarized in Chapter 4 and Chapter 5 respectively. Chapter 6 to Chapter 22 explains chemistry, properties, mechanism of action, structure activity relationships, chemistry of newer drugs and clinical uses of various therapeutic agents. At the end of book, a set of more than 200 essays and short questions and 225 objective questions with answers are strategically designed.
About the Author(s):
Dr. Rama Rao Nadendla
has been working as Professor in Pharmaceutical Chemistry department of KVSR Siddhartha College of Pharmaceutical Sciences, Vijayawada. He has 17 years teaching various pharmaceutical chemistry subjects. He secured Gold Medal (1987) from Gulbarga University, Gulbarga and graduated in Distinction from BITS, Pilani and was awarded Ph.D. by JNTU, Hyderabad under the guidance of Prof. K.P.R. Chowdary.
He has over sixty publications which include research and review papers in National/International Journals. He is an Editorial Advisory Board member of International Journal of Pharmaceutical Excipients and Pharma Review. He received Prof. M.L. Khurana Memorial Best Research paper Award from IJPSC in 2001. He is the author of Textbook of Pharmaceutical organic chemistry (Victory Publishers), Principles of Pharmaceutical Organic Chemistry (Revised and Enlarged, Macmillan India Pvt. Limited) and Pharmaceutical Organic Chemistry (Heterocyclics and Natural Products, Valabh Prakasan).
Contents:
Introduction to Medicinal Chemistry
General Principles of Drug Action
Physicochemical Properties of Organic Medicinal Agents
Chemistry of Prodrugs
Drug Metabolism
General Anesthetics
Sedative Hypnotic Drugs
Psychoactive Drugs
Antiepileptic Agents
Cholinergic and Anticholinergic Drugs
Adrenergic Drugs
Adrenoreceptor Blocking Drugs
Skeletal Muscle Relaxants
Antihistamines
Narcotic Analgesics
Narcotic Antagonists
Antitussives
Non-Steroidal Anti-Inflammatory Agents
Local Anesthetics
Diuretics
Publisher: New Age International
Edition Number: 1
EAN: 9788122415711
No. of Pages: 330
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# Hardcover: 192 pages
# Publisher: Facts on File (January 2007)
# Language: English
# ISBN-10: 081605276X
# ISBN-13: 978-0816052769
Specifications
Black-and-white photographs and line illustrations. Index. Appendixes. Bibliography. Glossary. Further reading. Web sources.
Summary
Drug development and research offer some of the most challenging and exciting research in the field of chemistry. Chemistry of Drugs provides an introduction to the most common processes by which chemists design and develop drugs today. It describes the chemical principles on which those processes are based, along with an overview of the applications and hazards associated with a variety of drugs available both legally and illegally.
Coverage also includes attempts to find and develop new natural products for use as drugs; the potential for curing diseases, such as cancer; the growing field of biotechnology; and combinational chemistry, a method of producing, evaluating, and developing new chemical compounds with possible value as drugs. Designer drugs are also discussed, as well as important social, economic, and political issues related to the development and use of drugs. Biographical information on many influential figures involved in the advancement of this field throughout history completes this enlightening volume.
Chapters include:
* Understanding the Way Drugs Work in the Body
* Natural Products
* Recombinant DNA as a New Source of Drugs
* Designer Drugs
* Rational Drug Design: Structure-Activity Relationships and Combinatorial Chemistry.
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