Nonpeptidic Inhibitors of Human Leukocyte Elastase. 3. Design, Synthesis, X-ray Crystallographic Analysis, and Structure-Activity Relationships for a Series of Orally Active 3-Amino-6-phenyl-2-pyridinyl Trifluoromethyl Ketones
Peter R. Bernstein, Don Andisik, Prudence K. Bradley, Craig B. Bryant, Christopher Ceccarelli, James R. Damewood Jr., Roger Earley, Philip D. Edwards, Scott Feeney,
J. Med. Chem., 1994, 37 (20), pp 3313–3326
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http://dx.doi.org/10.1021/jm00046a016