Biphenylsulfonamide Endothelin Receptor Antagonists. 4. Discovery of N-[[2‘-[[(4,5-Dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1‘-biphenyl]- 2-yl]methyl]-N,3,3-trimethylbutanamide (BMS-207940), A Highly Potent and Orally Active ETA Selective Antagonist
Natesan Murugesan,* Zhengxiang Gu, Steven Spergel, Marian Young, Ping Chen, Arvind Mathur, Leslie Leith, Mark Hermsmeier, Eddie C.-K. Liu, Rongan Zhang, Eileen Bird, Tom Waldron, Anthony Marino, Barry Koplowitz, W. Griffith Humphreys, Saeho Chong, Richard A. Morrison, Maria L. Webb, Suzanne Moreland, Nick Trippodo, and Joel C. Barrish*
J. Med. Chem., 2003, 46 (1), pp 125–137
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http://dx.doi.org/10.1021/jm020289q
