Biphenylsulfonamide Endothelin Antagonists: Structure−Activity Relationships of a Series of Mono- and Disubstituted Analogues and Pharmacology of the Orally Active Endothelin Antagonist 2‘-Amino-N- (3,4-dimethyl-5-isoxazolyl)-4‘-(2-methylpropyl)[1,1‘-biphenyl]-2-sulfonamide (BMS-187308)
Natesan Murugesan, Zhengxiang Gu, Philip D. Stein, Sharon Bisaha, Steve Spergel, Ravi Girotra, Ving G. Lee, John Lloyd, Raj N. Misra, Joan Schmidt, Arvind Mathur, Leslie Stratton, Yolanda F. Kelly, Eileen Bird, Tom Waldron, Eddie C.-K. Liu, Rongan Zhang, Helen Lee, Randy Serafino, Benoni Abboa-Offei, Parker Mathers, Mary Giancarli, Andrea Ann Seymour, Maria L. Webb, Suzanne Moreland, Joel C. Barrish, and John T. Hunt
J. Med. Chem., 1998, 41 (26), pp 5198–5218
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http://dx.doi.org/10.1021/jm970872k