Structure-Activity Relationship of 6-Methylidene Penems Bearing 6,5 Bicyclic Heterocycles as Broad-Spectrum β-Lactamase Inhibitors: Evidence for 1,4-Thiazepine Intermediates with C7 R Stereochemistry by Computational Methods.
Aranapakam M. Venkatesan, Atul Agarwal, Takao Abe, Hideki Ushirogochi, Itsuka Yamamura, Mihira Ado, Takasaki Tsuyoshi, Osvaldo Dos Santos, Yansong Gu, Fuk-Wah Sum, Zhong Li, Gerry Francisco, Yang-I Lin, Peter J. Petersen, Youjun Yang, Toshio Kumagai, William J. Weiss, David M. Shlaes, James R. Knox, and Tarek S. Mansour
J. Med. Chem., 2006, 49 (15), pp 4623–4637
- DOI:
http://dx.doi.org/10.1021/jm060021p
