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Clarke's Analysis of Drugs and Poisons 4th edition
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This reference work has been completely revised and updated for the new edition, and comprises two volumes.
Volume one
Part one: methodology and analytical techniques
Contains 44 chapters by leading international scientists covering the practice areas and analytical procedures used in toxicology
Volumes two
Parts two and three: analytical and toxicological data
Contains 2111 drug and poison monographs detailing physical properties, analytical methods, pharmacokinetic data and toxicity data.
Part four: Indexes to analytical data
This part contains indexes of analytical data, including all data for colour tests, chromatography, ultraviolet spectrophotometry, infrared spectrometry and mass spectrometry.
What's new?
Volume one has been greatly expanded from 31 to 44 chapters providing extensive coverage of all methodology and analytical techniques. Of significant interest include:
Quality control and assessment - separated into two chapters to reflect the differing situations/purposes/remits of the toxicology laboratory versus the pharmaceutical industry (accreditation with ISO17025 becoming the international standard in labs)
Method development and validation - now present since reliable analytical techniques and data should be of the utmost importance to any analyst 'Sampling, storage and stability', 'Measuring and reporting uncertainty' and 'Interpretation of results' now included to cover all aspects accreditation Pharmacokinetics now coupled with Pharmacogenomics
All chapters have been updated, for instance the colour test chapter now includes the analysis of metals, while newer analytical techniques, such as liquid chromatography-mass spectrometry (LC-MS) and atomic absorption spectrometry-inductively coupled- mass spectrometry (AAS-ICP-MS) are also covered.
Parts two and three now contain 2111 monographs (1730 in 3rd edition). This includes over 200 new monographs with retention of all monographs included in previous edition. New monographs include metals, natural toxins and weapons of mass destruction
Over 300 updated monographs including amphetamine, morphine and MDMA
