+++J. Med. Chem. (6 статей)

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1)Non-prostanoid thromboxane A2 receptor antagonists with a dibenzoxepin ring system. 2
Etsuo Ohshima, Hitoshi Takami, Hideyuki Sato, Shinichiro Mohri, Hiroyuki Obase, Ichiro Miki, Akio Ishii, Shiro Shirakura, Akira Karasawa, Kazuhiro Kubo
J. Med. Chem., 1992, 35 (18), pp 3402–3413
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http://dx.doi.org/10.1021/jm00096a017

2)Synthesis and structure-activity relationships of novel benzimidazole and imidazo[4,5-b]pyridine acid derivatives as thromboxane A2 receptor antagonists
Eric Nicolai, Joel Goyard, Thierry Benchetrit, Jean Marie Teulon, Francois Caussade, Angela Virone, Chantal Delchambre, Alix Cloarec
J. Med. Chem., 1993, 36 (9), pp 1175–1187
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http://dx.doi.org/10.1021/jm00061a008

3)Non-prostanoid thromboxane A2 receptor antagonists with a dibenzoxepin ring system. 1
Etsuo Ohshima, Hitoshi Takami, Hideyuki Sato, Hiroyuki Obase, Ichiro Miki, Akio Ishii, Akira Karasawa, Kazuhiro Kubo
J. Med. Chem., 1992, 35 (18), pp 3394–3402
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http://dx.doi.org/10.1021/jm00096a016

4)Development of Dual-Acting Benzofurans for Thromboxane A2 Receptor Antagonist and Prostacyclin Receptor Agonist: Synthesis, Structure−Activity Relationship, and Evaluation of Benzofuran Derivatives
Michihiro Ohno,* Mitsuko Miyamoto, Kazuhiro Hoshi, Takahiro Takeda, Naohiro Yamada, and Atsushi Ohtake
Pharmaceutical Research Laboratories, Toray Industries, Inc., 1,111 Tebiro, Kamakura, Kanagawa, 248-8555, Japan
J. Med. Chem., 2005, 48 (16), pp 5279–5294
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http://dx.doi.org/10.1021/jm050194z

5)Dibenz[b,e]oxepin derivatives: novel antiallergic agents possessing thromboxane A2 and histamine H1 dual antagonizing activity. 1
Etsuo Ohshima, Hitoshi Takami, Hiroyuki Harakawa, Hideyuki Sato, Hiroyuki Obase, Ichiro Miki, Akio Ishii, Hidee Ishii, Yasuo Sasaki,
J. Med. Chem., 1993, 36 (3), pp 417–420
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http://dx.doi.org/10.1021/jm00055a013

6)The Discovery of 4-{1-[({2,5-Dimethyl-4-[4-(trifluoromethyl)benzyl]-3-thienyl}carbonyl)amino]cyclopropyl}benzoic Acid (MK-2894), A Potent and Selective Prostaglandin E2 Subtype 4 Receptor Antagonist
Marc Blouin*‡, Yongxin Han*‡, Jason Burch‡, Julie Farand‡, Christophe Mellon‡, Mireille Gaudreault§, Mark Wrona§, Jean-Franois Lvesque§, Danielle Denis, Marie-Claude Mathieu, Rino Stocco, Erika Vigneault, Alex Therien, Patsy Clark, Steve Rowland, Daigen Xu, Gary O’Neill, Yves Ducharme‡ and Rick Friesen
J. Med. Chem., 2010, 53 (5), pp 2227–2238
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http://dx.doi.org/10.1021/jm901771h

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