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Optimization of the indolyl quinolinone class of KDR (VEGFR-2) kinase inhibitors: effects of 5-amido- and 5-sulphonamido-indolyl groups on pharmacokinetics and hERG binding
Mark E. Fraley, , Kenneth L. Arrington, Carolyn A. Buser, Patrice A. Ciecko, Kathleen E. Coll, Christine Fernandes, George D. Hartman, William F. Hoffman, Joseph J. Lynch, Rosemary C. McFall, Keith Rickert, Romi Singh, Sheri Smith, Kenneth A. Thomas, Bradley K. Wong
Bioorganic & Medicinal Chemistry Letters
Volume 14, Issue 2, January 2004, Pages 351–355
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http://dx.doi.org/10.1016/j.bmcl.2003.11.007