+++thanx dear

[pyrazole]

thanx

[mishka]

from Chemical Abstr.:
Seventeen title compds. (I; R1 = heptyl, nonyl, or CH2CH:C(Cl)Me; R2 = NMe2, NEt2, piperidino, cyclohexylamino, NHCH2Ph, piperazino, morpholino, NHNH2, N(CH2CH2OH)2, etc.) were prepd. by reacting the K salt of 8-bromo-3-methylxanthine with appropriate alkyl halides followed by condensation with appropriate primary or secondary amines. Toxicity studies in mice showed I to be less toxic than aminazine. Most I exhibited diuretic activity in rats, and some exhibited analeptic activity as well. Many I exhibited antimicrobial activity in vitro against both bacteria and fungi. The most active diuretics contained morpholino, piperidino, or N-benzyl groups at the 8-position.

article (Ukranian) here:

[KCN]

article belongs to

1
“Synthesis and biological activity of 3-methyl, 7 -or 8-alkyl, 7,8-dialkyl, heterocyclic, and cyclohexylaminoxanthines,
”Romanenko et al.,
Farmatsevtichnii Zhurnal, 1986, (Kiev), vol. 5, 1986, pp. 41-44.
Chem Abst Acc No 106:95577