+++Поиск по Reaxys/SF Спасибо, mishka!

[mbshch]

Здравствуйте, коллеги!
Пожалуйста, помогите с литературой по
2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one
СAS 277299-70-4

Заранее благодарю

[mishka]

полученике из ацетоуксусного эфира и 3,4-диметилфенилгидразина*HCl

With sodium bicarbonate; sodium acetate In diethyl ether; acetic acid


76%
Current Patent Assignee: LIGAND PHARMACEUTICALS - US2004/53299, 2004, A1


With sodium acetate In acetic acid for 24h; Heating / reflux;
76%
Current Patent Assignee: NOVARTIS - US2004/19190, 2004, A1
Location in patent: Page 17




With sodium acetate; acetic acid for 24h; Reflux;
76%
Current Patent Assignee: HETERO RESEARCH FOUNDATION - WO2016/35018, 2016, A1
Location in patent: Page/Page column 13

получение из ацетоуксусного эфира и 3,4-диметилфенилгидразина

In acetic acid

64%
Current Patent Assignee: SMITHKLINE BEECHAM - US6552008, 2003, B1
---
превращения описаны в

Current Patent Assignee: SICHUAN HAIRONG PHARMACEUTICAL - CN108191763, 2018, A
Location in patent: Paragraph 0056; 0062; 0063; 0064; 0065; 0068; 0069

Current Patent Assignee: NANJING HENGTONG PHARMACEUTICAL DEV - CN111518029, 2020, A
Location in patent: Paragraph 0036; 0039; 0041; 0044; 0046; 0049; 0051; 0054;

Current Patent Assignee: AMNEAL PHARMACEUTICALS - WO2017/81014, 2017, A1
Location in patent: Page/Page column 15; 16; 18

Srinivasachary, Katuroju; Rajesh, Chennuri; Tiwari, Shashikant; Somannavar; Nadakudity, Sailendra Kumar; Moturu, Krishna Murthy V.R.; Bhanuchadar, Samala; Ramadevi, Bhoomireddy
[Asian Journal of Chemistry, 2021, vol. 33, # 1, p. 97 - 102]

Current Patent Assignee: NOVARTIS - US2004/19190, 2004, A1
Location in patent: Page 17

Current Patent Assignee: SHANGHAI ABA CHEMICALS - CN109096195, 2018, A
Location in patent: Paragraph 0021-0026; 0028-0033; 0035-0040

Current Patent Assignee: CHANGZHOU PHARMACEUTICAL FACTORY - CN107021928, 2022, B
Location in patent: Paragraph 0058-0061
==========
масс и
1H ЯМР
dimethylsulfoxide-d6
1H NMR (300 MHz, d6-DMSO) δ 11.30 (br s, 1H), 7.49 (d, J=1.4 Hz, 1H), 7.43 (dd, J=8.2 Hz, 1H), 7.14 (d, J=8.2 Hz, 1H), 5.31 (s, 1H), 2.20 (s, 3H), 2.22 (s, 3H), 2.08 (s, 3H)
Signals given
Current Patent Assignee: NOVARTIS - US2004/19190, 2004, A1

куча ссылок на Pharmacological Data
например
Current Patent Assignee: SMITHKLINE BEECHAM - US6552008, 2003, B1

Abstract
Current Patent Assignee: GLAXOSMITHKLINE - US6642265, 2003, B1


Abstract
Current Patent Assignee: LIGAND PHARMACEUTICALS - US6670387, 2003, B1


Abstract
Current Patent Assignee: NOVARTIS - US2004/19190, 2004, A1

Abstract
Current Patent Assignee: LIGAND PHARMACEUTICALS - US2004/53299, 2004, A1


Abstract
Current Patent Assignee: GLAXOSMITHKLINE - US6720345, 2004, B1

Abstract
Current Patent Assignee: GLAXOSMITHKLINE - WO2007/44982, 2007, A2

Abstract
Current Patent Assignee: SMITHKLINE BEECHAM - WO2008/73864, 2008, A1

Abstract
Current Patent Assignee: PROTIA - US2009/76112, 2009, A1


Details

Abstract
Current Patent Assignee: SHANGHAI HENGRUI MEDICINE - WO2009/103218, 2009, A1

Abstract
Current Patent Assignee: NISSAN CHEMICAL INDUSTRIES - WO2004/33433, 2004, A1

Abstract
Current Patent Assignee: LIGAND PHARMACEUTICALS - WO2005/118551, 2005, A2


Abstract
Current Patent Assignee: TEVA PHARMACEUTICALS USA - US2010/256212, 2010, A1


Abstract
Liu, Kevin K.-C.; Sakya, Subas M.; O'Donnell, Christopher J.; Flick, Andrew C.; Li, Jin[Bioorganic and Medicinal Chemistry, 2011, vol. 19, # 3, p. 1136 - 1154]

Cited 82 times


Abstract
Current Patent Assignee: TEVA PHARMACEUTICALS USA - WO2013/49605, 2013, A1

Abstract
Current Patent Assignee: QILU PHARMACEUTICAL - WO2013/152683, 2013, A1

Abstract
Current Patent Assignee: GALCHIMIA SL - EP2799425, 2014, A1


Abstract
Current Patent Assignee: GALCHIMIA SL - WO2014/177517, 2014, A1


Abstract
Current Patent Assignee: GLENMARK LIFE SCIENCES - US2015/87845, 2015, A1

Abstract
Current Patent Assignee: HETERO RESEARCH FOUNDATION - WO2016/35018, 2016, A1