+++Поиск по Reaxys или SF, спасибо, mishka!!!

[_____Mr_Heisenberg]

Помогите найти методы синтеза

Код: Выделить всё

Lavendamicin

из

Код: Выделить всё

3-nitropyridines

noname01.mol

[mishka]

в реаксисе нет синтеза структуры-продукта, кот. нарисована вообще.
по имени лавендамицин находит один синтез - гидролиз метилового эфира
With potassium carbonate in methanol; water
Ambient temperature;
Kende; Ebetino
Tetrahedron Letters, 1984 , vol. 25, # 9 p. 923 - 926

[mishka]

из реаксиса по субструктуре
LavendamYcin
(синтез)

и некоторые ссылки, где явно в названии LavendamYcin фигурирует из 48 (всего в SF)
Synthesis of carbolines by transition-metal-catalyzed [2+2+2]-cycloaddition of alkynes and nitriles: A new way to the total synthesis of lavendamycin. Nissen, Felix. Germany. Avail. Deutsche Nationalbibliothek, Order No. 1010625012. (2008), No pp. From: DissOnline [Ger. Diss.] 2008, (D1126-3), No pp. given. http://d-nb.info/1010625012/34 Dissertation written in German. CAN 159:26262 AN 2012:1721782 CAPLUS
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Synthesis of lavendamycin. Rao, A. V. Rama; Chavan, Subhash P.; Sivadasan, Latha. Natl. Chem. Lab., Pune, 411 008, India. Tetrahedron (1986), 42(18), 5065-71. CODEN:TETRAB ISSN:0040-4020. Journal written in English. CAN 106:119513 AN 1987:119513 CAPLUS
ABSTRACT
A regioselective and convergent synthesis of lavendamycin (I) starting from 8-hydroxyquinoline and indole via Bischler-Napieralski cyclization is described.
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An approach towards synthesis of lavendamycin. Rao, A. V. Rama; Chavan, Subash; Sivadasan, Latha. Natl. Chem. Lab., Pune, 411 008, India. Indian J. Chem., Sect. B (1984), 23B(6), 496-7. CODEN:IJSBDB ISSN:0376-4699. Journal written in English. CAN 101:191468 AN 1984:591468 CAPLUS
ABSTRACT
The lavendamycin analog I was prepd. from 8-quinolinol and indole via amidation of β-methyltryptophan Me ester with 8-methoxyquinaldic acid and cyclization of the amide.
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Isolation of lavendamycin. A new antibiotic from Streptomyces lavendulae. Balitz, D. M.; Bush, J. A.; Bradner, W. T.; Doyle, T. W.; O'Herron, F. A.; Nettleton, D. E. Res. Div., Bristol-Myers Co., Syracuse, NY, 13201, USA. J. Antibiot. (1982), 35(3), 259-65. CODEN:JANTAJ ISSN:0021-8820. Journal written in English. CAN 96:196237 AN 1982:196237 CAPLUS
ABSTRACT
lavendamycin (I) [81645-09-2], an antibiotic closely related to streptonigrin, was isolated from the fermn. medium of S. lavendulae by extn. with BuOH, followed by high-pressure liq. chromatog. and TLC. I displayed a broad-spectrum activity against both gram-pos. and gram-neg. bacteria as well as against yeast and fungi. I was particularly active against dermatophytes, with min. inhibitory concns. of 0.25-0.5 μg/mL. In addn., I had antitumor activity when administered to mice with P-388-J leukemia.