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[Medz]

Помогите пожалуйста найти методики синтеза данного соединения
2-chloro-3-(dimethoxymethyl)pyridine
C1(Cl)=NC=CC=C1C(OC)OC

1.GIF

C1.mol

[mishka]

реакс

[Medz]

Большое спасибо !!!

[dbv_4u]

To a solution of 2-chloro 3-bromopyridine (1.0 eq) in dry THF was added isopropylmagnesium chloride (2.0 M, 1.1 eq) dropwise with the temperature not exceeding 5°C under N2 atmosphere. the reaction was monitored by TLC After 30-60min, Dry trimethyl orthoformate was added dropwise maintaining the temperature 0 °C. After 30-60min. at room temperature, the mixture was quenched by addition of Sat.NH4Cl Soln. the extraction with ether, and evaporation of solvent give you desired product in quantitative yield.