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[urri]

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C1CCn2c(CN1)cnc2
C1NCc2cncn2C1

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[mishka]

есть 6 членный

из 7-benzyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine
With 10% Pd/C; hydrogen In ethanol under 750.075 Torr;

Experimental Procedure
2.52 g
Current Patent Assignee: ESTEVE PHARMACEUTICALS - WO2015/91795, 2015, A1
Location in patent: Paragraph 36



Abstract
C.1 C.1. 5,6,7,8-Tetrahydroimidazo[1 ,5-a]pyrazine
7-Benzyl-5,6,7,8-tetrahydroimidazo[1 ,5-a]pyrazine (4.89 g, 22.9 mmol) was dissolved in absolute ethanol (200 mL) and 10% palladium on carbon (4.88 g) was added to the solution. The mixture was placed under 1 bar of a hydrogen atmosphere and stirred vigorously overnight. Then it was filtered through celite rinsing with ethanol, concentrated and coevaporated with dichloromethane. The title compound was obtained as off-white oil (2.52 g).1H NMR (ODd3) 6 7.42 (s, 1H), 6.77 (s, 1H), 4.07 (s, 2H), 3.99 (t, J = 5.6 Hz, 2H),3.22 (t, J = 5.6 Hz, 2H), 1.76 (br s, 1 H). LC/MS m/z 124 [M+H].




трифторацетат
Current Patent Assignee: MERCK SHARP DOHME - US2003/236250, 2003, A1
Location in patent: Page 41

[urri]

Спасибо!