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Помогите пожалуйста найти способы получения сульфасалазина. C18H14N4O5S, mol-файл прилагается..

2-hydroxy-5-{[4-(pyridin-2-ylsulfamoyl)phenyl]diazenyl}benzoic acid
CAS: 599-79-1
SMILES: O=S(=O)(Nc1ccccn1)c3ccc(/N=N/c2cc(C(O)=O)c(O)cc2)cc3

Зарание спасибо!

[suprachemister]

sulfasalazine.PNG

Method of producing 2-hydroxy-5-[[4-[(2-pyridinylamino)sulfonyl]phenyl]azo]benzoic acid [sulfasalazine]
By Novacek, Alois; Sedlackova, Venuse; Korner, Jaroslav; Hromas, Josef; Dundr, Vladimir; Brunova, Bohumila; Kejha, Jiri
From Czech. (1992), CS 273928 B1 19910411. Language: Czech

The drug sulfasalazine (I) is prepd. from sulfapyridine (II) and salicylic acid (III) by an improved method which results in fewer impurities. II is diazotized by aq. NaNO2 in excess HCl, and the resulting diazonium salt is coupled with excess III and/or its salt (mol ratio II/III = 1:1.25) in excess aq. NaOH; the unreacted III is sepd. by gradual acidification with HCl and AcOH to pH 4.5, at which point it remains in soln. After crude I is filtered, it is further purified by treatment with dil. HCl and EtOH or MeOH. Crude, dry I may also be purified by crystn. from a mixt. of EtOH, EtOAc, and concd. HCl, and crude, wet I may be purified by treatment with dil. AcOH and dil. HCl. The method, which also used urea to quench excess HONO before coupling, gave approx. 70% yield of chromatog. pure I.

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Suprachemister, спасибо!