Scifinder request

[elwology]

Please search for the attached compounds as reactant and product.
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Scifinder.rar

[AlRoman]

Compound №1: As reactant - O, As product - О.
Compound №2:
As product:
1. Structurally Constrained Hybrid Derivatives Containing Octahydrobenzo[g or f]quinoline Moieties for Dopamine D2 and D3 Receptors: Binding Characterization at D2/D3 Receptors and Elucidation of a Pharmacophore Model Full Text By Brown, Dennis A.; Kharkar, Prashant S.; Parrington, Ingrid; Reith, Maarten E. A.; Dutta, Aloke K.
From Journal of Medicinal Chemistry (2008), 51(24), 7806-7819. | Language: English, Database: CAPLUS
A series of structurally constrained analogs based on hybrid compds. contg. octahydrobenzo[g or f]quinoline moieties were designed, synthesized, and characterized for their binding to dopamine D2 and D3 receptors expressed in HEK-293 cells. Among the newly developed constrained mols., trans-octahydrobenzo[f]quinolin-7-ol (I) exhibited the highest affinity for D2 and D3 receptors, the (-)-isomer being the eutomer. Interestingly, this hybrid constrained version I showed significant affinity over the corresponding nonhybrid version II (representing a constrained version of the aminotetralin str...

2. Ruthenium(III) chloride-catalyzed efficient protocol for ethyl diazoacetate insertion into the N-H bond of secondary amines Full Text By Varala, Ravi; Enugala, Ramu; Adapa, Srinivas R.
From Monatshefte fuer Chemie (2008), 139(11), 1369-1372. | Language: English, Database: CAPLUS
Ruthenium(III) chloride (1 mol%) alone can catalyze the insertion of Et diazoacetate into N-H bonds of various structurally and electronically diverse secondary cyclic amines under solvent-free conditions to afford the corresponding glycine esters in good yields under ambient conditions. Reactions with various aliph. primary and arom. amines examd., however, were unsuccessful.

3. Synthesis of substituted piperazinyl semicarbazides and thiosemicarbazide: as possible acetyl cholinesterase (AChE) inhibitors Full Text By Sengupta, Anil K.; Agarwal, K. C.; Mushtaq, M.
From Journal of the Indian Chemical Society (1977), 54(10), 961-4. | Language: English, Database: CAPLUS
The title semicarbazides I (R1 = H, 2-, 3-, 4-Me; R2 = Ph, 2-, 3-, 4-MeC6H4, 4-ClC6H4, 4-BrC6H4; Z = S, O) (24 compds.) were prepd. by N-alkylating II with ClCH2CO2Et to give III, amidating III with NH2NH2 to give IV followed by treating IV with R2NCZ. Six I (Z = S; R = H, 3-, 4-Me; R1 = Ph, 2-, 3-MeC6H4, 4-BrC6H4) showed marginal inhibition of acetylcholinesterase activity.
As reactant:
1. Structurally Constrained Hybrid Derivatives Containing Octahydrobenzo[g or f]quinoline Moieties for Dopamine D2 and D3 Receptors: Binding Characterization at D2/D3 Receptors and Elucidation of a Pharmacophore Model Full Text By Brown, Dennis A.; Kharkar, Prashant S.; Parrington, Ingrid; Reith, Maarten E. A.; Dutta, Aloke K.
From Journal of Medicinal Chemistry (2008), 51(24), 7806-7819. | Language: English, Database: CAPLUS
A series of structurally constrained analogs based on hybrid compds. contg. octahydrobenzo[g or f]quinoline moieties were designed, synthesized, and characterized for their binding to dopamine D2 and D3 receptors expressed in HEK-293 cells. Among the newly developed constrained mols., trans-octahydrobenzo[f]quinolin-7-ol (I) exhibited the highest affinity for D2 and D3 receptors, the (-)-isomer being the eutomer. Interestingly, this hybrid constrained version I showed significant affinity over the corresponding nonhybrid version II (representing a constrained version of the aminotetralin str...

2. Heterocyclic compounds. I. Syntheses of 1,3,5-triazine derivatives and their pharmacological activities. 1 Full Text By Tsujikawa, Teruaki; Takei, Saburo; Tsushima, Susumu; Tsuda, Takashi; Tsukamura, Kazuo; Sirakawa, Kenzo; Chiba, Sukehiro; Nagawa, Yuji; Yui, Tohoru
From Yakugaku Zasshi (1975), 95(5), 499-511. | Language: Japanese, Database: CAPLUS
6-Alkoxy-2-alkyl-4-amino-1,3,5-triazines and related compds. were synthesized and their pharmacol. activities were examd. Main characteristics of these compds. after their intraperitoneal administration were divided into two categories, sedation and convulsion. The sedative effect was parallel to potentiation of barbiturate hypnosis. No clear relationship was found between anticonvulsant and sedative effects. In many cases, the compds. with phenylpiperazinyl group produced fall in blood pressure. This hypotension seems to be due at least in part, to central action of the compd.
Compounds №3:
As product:
1. Novel quinazolinone derivatives as 5-HT7 receptor ligands Full Text By Na, Yong Ho; Hong, Sung Ho; Lee, Jung Hyang; Park, Woo-Kyu; Baek, Du-Jong; Koh, Hun Yeong; Cho, Yong Seo; Choo, Hyunah; Pae, Ae Nim
From Bioorganic & Medicinal Chemistry (2008), 16(5), 2570-2578. | Language: English, Database: CAPLUS
5-HT7 receptor antagonists generated antidepressant-like effects in animal model and the involvement of the 5-HT7 receptor in other pathophysiol. mechanisms such as thermoregulation, learning and memory, and sleep has been highlighted by various studies. As one of our efforts to discover a new type of 5-HT7 receptor antagonists, we here report on the synthesis and binding affinities to the 5-HT7 receptor of the quinazolinone library 1, which was designed with various substituents (X, Y, R1, and R2) on the arom. rings and different carbon chain length. Total 85 compds. of the quinazolinone li...

2. Samarium(III) triflate catalyzed conjugate addition of amines to electron-deficient alkenes Full Text By Yadav, J. S.; Reddy, A. Ramesh; Rao, Y. Gopal; Narsaiah, A. V.; Reddy, B. V. Subba
From Synthesis (2007), (22), 3447-3450. | Language: English, Database: CAPLUS
Amines undergo smooth nucleophilic addn. to α,β-unsatd. compds. in the presence of a catalytic amt. of samarium(III) triflate at ambient temp. to produce β-amino compds. in excellent yields. This method is simple, convenient, and works efficiently under mild conditions.

3. Lanthanum trichloride (LaCl3), an efficient catalyst for conjugate addition of amines to electron-deficient olefins Full Text By Narsaiah, Akkirala Venkat
From Letters in Organic Chemistry (2007), 4(7), 462-464. | Language: English, Database: CAPLUS
Electron-poor alkenes undergo rapid conjugate addn. with a wide range of amines in the presence of lanthanum trichloride at room temp. to produce the corresponding 2-amino compds. in excellent yields.

As reactant:
1. Novel quinazolinone derivatives as 5-HT7 receptor ligands Full Text By Na, Yong Ho; Hong, Sung Ho; Lee, Jung Hyang; Park, Woo-Kyu; Baek, Du-Jong; Koh, Hun Yeong; Cho, Yong Seo; Choo, Hyunah; Pae, Ae Nim
From Bioorganic & Medicinal Chemistry (2008), 16(5), 2570-2578. | Language: English, Database: CAPLUS
5-HT7 receptor antagonists generated antidepressant-like effects in animal model and the involvement of the 5-HT7 receptor in other pathophysiol. mechanisms such as thermoregulation, learning and memory, and sleep has been highlighted by various studies. As one of our efforts to discover a new type of 5-HT7 receptor antagonists, we here report on the synthesis and binding affinities to the 5-HT7 receptor of the quinazolinone library 1, which was designed with various substituents (X, Y, R1, and R2) on the arom. rings and different carbon chain length. Total 85 compds. of the quinazolinone li..