Тилорон, перекристаллизация субстанции

[cannizzaro]

Господа, может кто сталкивался, какой выбрать растворитель для перекристаллизации данной субстанции?

[suprachemister]

2,7-Bis[2-(diethylamino)ethoxy]-9H-fluoren-9-one Dihydro -
chloride (, Tilorone Hydrochloride ) . To a stirred mixture of
31.8 g (0.15 mol) of VI, 103.2 g (0.60 mol) of 2-diethylaminoethyl
chloride hydrochloride, 100 ml of H20 , and 450 ml of toluene, 66.0 g (1 mol)
of KOH pellets in 100 ml of H2O was added. This mixture
was stirred vigorously a t reflux temperature for 20 hr . The
mixture was allowed to cool; the toluene layer was separated,
washed with 20% KOH and saturated NaCl solution, and then
dried (MgS04) . After filtration and evaporation of solvents, the
residue was dissolved in i -PrOH and acidified with ethanolic HCl.
The orange product (55.6 g) was recrystallized from i-PrOH-MeOH
to give 51.6 g (72%) of Tilorone Hydrochloride, mp 235-236" dec.

[Barium]

Благодарю, коллега! Жаль не дано соотношение растворителей ИПСа и метанола Субстанция дорогая, жаль переводить ее