Synthesis and biological activity of trans-(.+-.)-N-methyl-2-(3-pyridyl)-2-tetrahydrothiopyrancarbothioamide 1-oxide (RP 49356) and analogs: a new class of potassium channel opener
Thomas J. Brown, Robert F. Chapman, David C. Cook, Terance W. Hart, Iain M. McLay, Roy Jordan, Jonathan S. Mason, Malcolm N. Palfreyman, Roger J. A. Walsh
J. Med. Chem., 1992, 35 (20), pp 3613–3624
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http://dx.doi.org/10.1021/jm00098a004