1) J. Med. Chem., 2010, 53 (9), pp 3611–3617
Yvonne Rook, Kai-Uwe Schmidtke, Friedemann Gaube, Dirk Schepmann, Bernhard Wnsch, Jrg Heilmann, Jochen Lehmann and Thomas Winckler
Bivalent β-Carbolines as Potential Multitarget Anti-Alzheimer Agents
- DOI:
http://dx.doi.org/10.1021/jm1000024
Bryan K. S. Yeung, Bin Zou, Matthias Rottmann, Suresh B. Lakshminarayana, Shi Hua Ang, Seh Yong Leong, Jocelyn Tan, Josephine Wong, Sonja Keller-Maerki, Christoph Fischli, Anne Goh, Esther K. Schmitt, Philipp Krastel, Eric Francotte, Kelli Kuhen, David Plouffe, Kerstin Henson, Trixie Wagner, Elizabeth A. Winzeler, Frank Petersen, Reto Brun, Veronique Dartois, Thierry T. Diagana and Thomas H. Keller
Spirotetrahydro β-Carbolines (Spiroindolones): A New Class of Potent and Orally Efficacious Compounds for the Treatment of Malaria
- DOI:
http://dx.doi.org/10.1021/jm100410f
Heba A. Mohamed, Nancy M. R. Girgis, Rainer Wilcken, Matthias R. Bauer, Heather N. Tinsley, Bernard D. Gary, Gary A. Piazza, Frank M. Boeckler, and Ashraf H. Abadi
Synthesis and Molecular Modeling of Novel Tetrahydro-β-carboline Derivatives with Phosphodiesterase 5 Inhibitory and Anticancer Properties
- DOI:
http://dx.doi.org/10.1021/jm100842v
Caiping Tan, Sensen Lai, Shouhai Wu, Sheng Hu, Lingjun Zhou, Yu Chen, Minxu Wang, Yiping Zhu, Wu Lian, Wenlie Peng, Liangnian Ji, and Anlong X
Nuclear Permeable Ruthenium(II) β-Carboline Complexes Induce Autophagy To Antagonize Mitochondrial-Mediated Apoptosis
- DOI:
http://dx.doi.org/10.1021/jm1009296
Tomoki Takeuchi, Shinya Oishi, Toshiaki Watanabe, Hiroaki Ohno, Jun-ichi Sawada, Kenji Matsuno, Akira Asai, Naoya Asada, Kazuo Kitaura, and Nobutaka Fujii
Structure–Activity Relationships of Carboline and Carbazole Derivatives as a Novel Class of ATP-Competitive Kinesin Spindle Protein Inhibitors
- DOI:
http://dx.doi.org/10.1021/jm200448n
Shinya Oishi, Toshiaki Watanabe, Jun-ichi Sawada, Akira Asai, Hiroaki Ohno and Nobutaka Fujii
. Kinesin Spindle Protein (KSP) Inhibitors with 2,3-Fused Indole Scaffolds
- DOI:
http://dx.doi.org/10.1021/jm100476d
Jiawang Liu, Xueyun Jiang, Ming Zhao, Xiaoyi Zhang, Meiqing Zheng, Li Peng and Shiqi Peng
A Class of 3S-2-Aminoacyltetrahydro-β-carboline-3-carboxylic Acids: Their Facile Synthesis, Inhibition for Platelet Activation, and High in Vivo Anti-Thrombotic Potency
- DOI:
http://dx.doi.org/10.1021/jm901816j
Wei Bi, Yue Bi, Ping Xue, Yanrong Zhang, Xiang Gao, Zhibo Wang, Meng Li, Michle Baudy-Floc’h, Nathaniel Ngerebara, K. Michael Gibson, and Lanrong Bi
Synthesis and Characterization of Novel Indole Derivatives Reveal Improved Therapeutic Agents for Treatment of Ischemia/Reperfusion (I/R) Injury
- DOI:
http://dx.doi.org/10.1021/jm100529e