Volume 16, Issue 21, 1 November 2006, Pages 5561-5566
Identification of isothiazole-4-carboxamidines derivatives as a novel class of allosteric MEK1 inhibitors
Hassan El Abdellaoui, a, , Chamakura V.N.S. Varaprasada, Dinesh Barawkara, Subrata Chakravartya, Andreas Madernaa, Robert Tama, Huanming Chena, Matt Allana, Jim Z. Wua, Todd Applebya, Shunqi Yana, Weijian Zhanga, Stanley Langa, Nanhua Yaoa, Robert Hamatakea and Zhi Honga
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http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TF9-4KR3J78-6&_user=10&_coverDate=11%2F01%2F2006&_rdoc=19&_fmt=high&_orig=browse&_srch=doc-info(%23toc%235221%232006%23999839978%23633899%23FLA%23display%23Volume)&_cdi=5221&_sort=d&_docanchor=&_ct=51&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=1c865f41614dacede242d2157ef9dec1
Volume 16, Issue 13, 1 July 2006, Pages 3444-3448
Discovery of novel isothiazole inhibitors of the TrkA kinase: Structure–activity relationship, computer modeling, optimization, and identification of highly potent antagonists
Blaise Lippa, , Joel Morris, Matthew Corbett, Tricia A. Kwan, Mark C. Noe, Sheri L. Snow, Thomas G. Gant, Melchiorra Mangiaracina, Heather A. Coffey, Barbara Foster, Elisabeth A. Knauth and Matthew D. Wessel
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http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TF9-4JT3S10-3&_user=10&_coverDate=07%2F01%2F2006&_rdoc=22&_fmt=high&_orig=browse&_srch=doc-info(%23toc%235221%232006%23999839986%23623283%23FLA%23display%23Volume)&_cdi=5221&_sort=d&_docanchor=&_ct=60&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=19972f68157b322f851412ce98c1b012
Efficient synthesis of fused isothiazole C-nucleosides. 1. Synthesis of a 3-.beta.-D-ribofuranosylisothiazolo[4,5-d]pyrimidin-7(6H)-one isostere of inosine
Heinrich Wamhoff, Rainer Berressem, Martin Nieger
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http://pubs.acs.org/doi/abs/10.1021/jo00071a030