Сообщение
mishka » Сб янв 15, 2022 12:25 am
реаксис (не хочет сохранять)
1) + глиоксаль
with sodium hydroxide In water at -10 - 22℃; for 4.67h;
выход - 91.2%
No author
CN111349049, 2020, A
Location in patent: Paragraph 0044-0048
Stage #1: Glyoxal; 2-aminopropanediamide In water at 90℃; for 3h;
Stage #2: With ammonia; dihydrogen peroxide In water at 0 - 20℃;
63%
No author
WO2007/144686, 2007, A1
Location in patent: Page/Page column 129-130
With phosphoric acid; sodium hydroxide In water at 20 - 30℃; for 1.5h;
118 g
No author
JP5739618, 2015, B2
Location in patent: Paragraph 0024
With phosphoric acid; sodium hydroxide In aq. phosphate buffer; water at 20 - 30℃; for 1.5h;
118 mg
No author
US2018/141920, 2018, A1
Location in patent: Paragraph 0215; 0216; 0217; 0218; 0219; 0220; 0221; 0222
With water; sodium hydroxide at -10 - 20℃;
No author
US2021/355090, 2021, A1
Location in patent: Paragraph 0023; 0335
2) до натриевой соли
With sodium hydroxide In water at -10 - 22℃; for 4.66667h;
92%
No author
US2011/275817, 2011, A1
Location in patent: Page/Page column 4-5
With lithium chloride; sodium hydroxide at 20℃; for 3.5h; Temperature;
88.2%
No author
CN111978263, 2020, A
Location in patent: Paragraph 0048-0053; 0068-0070
With sodium hydroxide at -10 - 20℃; for 4h;
Charoensetakul, Netnapa; Khamkhenshorngphanuch, Thitiphong; Srikun, Onsiri; Srimongkolpithak, Nitipol; Thongpanchang, Chawanee; Tiyasakulchai, Thanat; Yuthavong, Yongyuth
[RSC Advances, 2021, vol. 11, # 61, p. 38691 - 38693]
3) продукт в виде таутомера (оксо)
Stage #1: Glyoxal; 2-aminopropanediamide In water at 90℃; for 3h; Inert atmosphere;
Stage #2: With ammonium hydroxide; dihydrogen peroxide In water at 20℃; for 1h; pH=7; Inert atmosphere;
63%
Pierra, Claire; Counor, Clement; Storer, Richard; Gosselin, Gilles
[Collection of Czechoslovak Chemical Communications, 2011, vol. 76, # 11, p. 1327 - 1333]
Muehlmann; Day
[Journal of the American Chemical Society, 1956, vol. 78, p. 242]
Jones
[Journal of the American Chemical Society, 1949, vol. 71, p. 78,79, 80]
4) тоже как таутомер
With dihydrogen peroxide 1.) H2O, 80 deg C, 3 h; Yield given. Multistep reaction;
Lee; Chello; Chou; Templeton; Parham
[Journal of Medicinal Chemistry, 1983, vol. 26, # 2, p. 283 - 286]