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[urri]

Добрый день!
Посмотрите,пожалуйста,получение
Cc1nn(C)cc1CN
Или в общем виде N-алкил
путем восстановления соответствующего нитрила
алюмогидридом лития.
Спасибо!

[mishka]

с любым заместителем в 5 положении и если все метилы на алкилы заменить
то 2 реакции

из 5-methoxy-1,3-dimethyl-1H-pyrazole-4-carbonitrile в (5-methoxy-1,3-dimethyl-1H-pyrazol 4-yl)methanamine

With ammonia; hydrogen In methanol at 20℃; under 760.051 Torr; for 12h;
81%
Current Patent Assignee: EPIZYME - WO2015/200650, 2015, A1
Location in patent: Paragraph 0519; 0528


With ammonia; hydrogen In methanol at 20℃; for 12h; Temperature;

Experimental Procedure
Current Patent Assignee: EPIZYME - WO2015/10049, 2015, A1
Location in patent: Paragraph 0718


1.5 Step 5: Synthesis of (5-methoxy-l,3-dimethyl-lH-pyrazol-4-yl)methanamine
Step 5: Synthesis of (5-methoxy-l,3-dimethyl-lH-pyrazol-4-yl)methanamine: To a solution of 5-methoxy-l,3-dimethyl-lH-pyrazole-4-carbonitrile (3.5 g, 23.02 mmol) in methanol (40 mL), catalytic amount of Raney Nickel and ammonia solution (10 mL) were added. Reaction mass was stirred at room temperature under hydrogen pressure (balloon pressure) for 12h. On completion of reaction, reaction mass was filtered through celite bed, celite bed washed with methanol and filtrate was concentrated under reduced pressure to afford crude compound that was used in the next step without further purification (2.9 g, 80.8%).

и
из 5-chloro-1,3-dimethyl-1H-pyrazole-4-carbonitrile в (5-methoxy-1,3-dimethyl-1H-pyrazol 4-yl)methanamine

Multi-step reaction with 2 steps
1: methanol / 12 h / 0 - 60 °C
2: hydrogen; ammonia / methanol / 12 h / 20 °C


Current Patent Assignee: EPIZYME - WO2015/10049, 2015, A1


Multi-step reaction with 2 steps
1: methanol / 12 h / 0 - 60 °C
2: ammonia; hydrogen / methanol / 12 h / 20 °C / 760.05 Torr


Current Patent Assignee: EPIZYME - WO2015/200650, 2015, A1

[urri]

Спасибо!