Люди, у кого есть поисковик (Belshtain) или похожий, можете глянуть получение 1-гептилимидазола или просто кто с таким работал. Получить, то я получил по методике, но не известно откуда она (была на бумажке от предшественников), очень надо для статьи (именно ссылки на синтез и характеризацию). Думаю вещество впервые получено в году так 1950.
Заранее спасибо.
СержЛ.
1-гептилимидазол
Идете на http://www.spresi.com/ Это Бельштйен он-лайн.
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Регистрируетесь (Get your demo account now!). Получаете по мылу пароль и логин и делаете то, что Вам нужно. Мыл рассылается автоматически => быстро.
Спасибо, посмотрел, вещество простое, а оказалось только одна ссылка на непонятный журнал, у кторого сайта -то нет. Если кто еще имеет ссылки, может в русских журналах, сильно выручит информацией.Tasha писал(а):Идете на http://www.spresi.com/ Это Бельштйен он-лайн.
Регистрируетесь (Get your demo account now!). Получаете по мылу пароль и логин и делаете то, что Вам нужно. Мыл рассылается автоматически => быстро.
Phase transfer catalyzed synthesis and biological activities of a homologous series of 1-alkylimidazoles. De Savignac, A.; Roques, C.; Hinedi, M.; Michel, G.; Lattes, A. European Journal of Medicinal Chemistry 1990, 25(5), 449-54.
Abstract
A homologous series of 1-alkylimidazoles (pentyl to octadecyl) has been obtained with good yield (75-95%) by the phase transfer catalyzed reaction of imidazole with the appropriate alkyl halides. The antifungal and antibacterial activities of these compds. were tested. A poor activity was obsd. towards the Gram-neg. microorganisms, where the aerobic and anaerobic Gram-pos. microorganisms and some yeasts (Pityrosporum ovale) were inhibited. The inhibitory potency of such compds. increased with increasing chain length, passing through a max. with chain length C10-C13 and decreased for the higher homologs. An explanation is suggested in relation to the ability of these compds. to bind with the active sites of the microorganisms and to adopt a conformation able to promote the migration through the biol. membranes.
Synthesis of N-alkylated derivatives of imidazole as antibacterial agents. Khabnadideh, S.; Rezaei, Z.; Khalafi-Nezhad, A.; Bahrinajafi, R.; Mohamadi, R.; Farrokhroz, A. A. Department of Medicinal Chemistry, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran. Bioorganic & Medicinal Chemistry Letters 2003, 13(17), 2863-2865.
Abstract
N-Alkylation of imidazole, 2-methylimidazole and 2-methyl-4-nitroimidazole were carried out to achieve effective antibacterial agents. The products were then studied for antibacterial activity against Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa. Antibacterial effects of 1-alkylimidazole derivs. increase as the no. of carbons in alkyl chain increases up to nine carbons. Also substitution of 2-Me and 2-methyl-4-nitro groups on imidazole ring increases the antibacterial activity.
midazoliums, their intermediates and use. Diamond, Julius; Lumma, William Carl, Jr.; Morgan, Thomas Kenneth, Jr.; Wohl, Ronald Andre. (Schering A.-G., Fed. Rep. Ger.). Eur. Pat. Appl. (1985), 61 pp. CODEN: EPXXDW EP 131302 A2 19850116 Designated States R: AT, BE, CH, DE, FR, GB, IT, LI, LU, NL, SE. Patent written in English. Application: EP 84-108015 19840709. Priority: US 83-513143 19830712. CAN 103:37475
Structure-activity relations in the effects of 1-alkylimidazoles on microsomal oxidation in vitro and in vivo. Wilkinson, C. F.; Hetnarski, Krystyna; Cantwell, G. Patricia; Di Carlo, Frederick J. Dep. Entomol., Cornell Univ., Ithaca, NY, USA. Biochemical Pharmacology (1974), 23(17), 2377-86.
Abstract
A homologous series of 1-alkylimidazoles (pentyl to octadecyl) has been obtained with good yield (75-95%) by the phase transfer catalyzed reaction of imidazole with the appropriate alkyl halides. The antifungal and antibacterial activities of these compds. were tested. A poor activity was obsd. towards the Gram-neg. microorganisms, where the aerobic and anaerobic Gram-pos. microorganisms and some yeasts (Pityrosporum ovale) were inhibited. The inhibitory potency of such compds. increased with increasing chain length, passing through a max. with chain length C10-C13 and decreased for the higher homologs. An explanation is suggested in relation to the ability of these compds. to bind with the active sites of the microorganisms and to adopt a conformation able to promote the migration through the biol. membranes.
Synthesis of N-alkylated derivatives of imidazole as antibacterial agents. Khabnadideh, S.; Rezaei, Z.; Khalafi-Nezhad, A.; Bahrinajafi, R.; Mohamadi, R.; Farrokhroz, A. A. Department of Medicinal Chemistry, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran. Bioorganic & Medicinal Chemistry Letters 2003, 13(17), 2863-2865.
Abstract
N-Alkylation of imidazole, 2-methylimidazole and 2-methyl-4-nitroimidazole were carried out to achieve effective antibacterial agents. The products were then studied for antibacterial activity against Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa. Antibacterial effects of 1-alkylimidazole derivs. increase as the no. of carbons in alkyl chain increases up to nine carbons. Also substitution of 2-Me and 2-methyl-4-nitro groups on imidazole ring increases the antibacterial activity.
midazoliums, their intermediates and use. Diamond, Julius; Lumma, William Carl, Jr.; Morgan, Thomas Kenneth, Jr.; Wohl, Ronald Andre. (Schering A.-G., Fed. Rep. Ger.). Eur. Pat. Appl. (1985), 61 pp. CODEN: EPXXDW EP 131302 A2 19850116 Designated States R: AT, BE, CH, DE, FR, GB, IT, LI, LU, NL, SE. Patent written in English. Application: EP 84-108015 19840709. Priority: US 83-513143 19830712. CAN 103:37475
Structure-activity relations in the effects of 1-alkylimidazoles on microsomal oxidation in vitro and in vivo. Wilkinson, C. F.; Hetnarski, Krystyna; Cantwell, G. Patricia; Di Carlo, Frederick J. Dep. Entomol., Cornell Univ., Ithaca, NY, USA. Biochemical Pharmacology (1974), 23(17), 2377-86.
правда?..., это Бельштейн выдал, там глюки бывают. В мед. журналах часто нет характеристики веществ, в лучшем случае элементник. Хотя это не самый оптимальный вид анализа.Cherep писал(а):Чтото я в этой статье синтеза предмета обсуждения не заметилСержл писал(а):J. Med. Chem. 1987, 696
Спасибо что предупредили, этот журнал только в библиотеке, а тетки там уже давно того...чай пьют .
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