Нужна статья из Pol J Pharmacol Pharm.
Kinetics and mechanism of degradation of some 2-sulfanilamidopyrimidine derivatives. Part 1. Log k--pH profile for sulfadimidine solvolysis.
Zajac M.
Pol J Pharmacol Pharm. 1976;28(5):495-503.
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Kinetics and mechanism of degradation of some 2-sulfanilamidopyrimidine derivatives. Part 1. Log k--pH profile for sulfadimidine solvolysis. Zajac M Polish journal of pharmacology and pharmacy (1976), 28(5), 495-503. Journal code: 0366561. ISSN:0301-0244. Poland. Journal; Article; (JOURNAL ARTICLE) written in English.
Abstract
The degradation of sulfadimidine (SDMP) in the pH range 5-83--10-0, at 403, 411 and 418 K, was investigated by UV spectrophotometry. Semilogarythmic plots (A242--A') vs. time in 0-1 M HCl for the degradation of SDMP in the above pH range were linear. The log k--pH profile constructed from the experimental results served for estimation of specific rate constants and pKa values. These, in turn, were used to calculate the theoretical log k--pH profile, acc. to the equation for the rate of reaction proportional to the concentration of the dissociated form of SDMP, in the pH range 5-8--10. Thermodynamic parameters of the reaction--energy, entropy and enthalpy of activation and the frequency factor for the specific rate constants were determined.
Abstract
The degradation of sulfadimidine (SDMP) in the pH range 5-83--10-0, at 403, 411 and 418 K, was investigated by UV spectrophotometry. Semilogarythmic plots (A242--A') vs. time in 0-1 M HCl for the degradation of SDMP in the above pH range were linear. The log k--pH profile constructed from the experimental results served for estimation of specific rate constants and pKa values. These, in turn, were used to calculate the theoretical log k--pH profile, acc. to the equation for the rate of reaction proportional to the concentration of the dissociated form of SDMP, in the pH range 5-8--10. Thermodynamic parameters of the reaction--energy, entropy and enthalpy of activation and the frequency factor for the specific rate constants were determined.
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